Article
Molecular approaches to resolve diagnostic dilemmas: the case of gastrointestinal stromal tumor and leiomyosarcoma.
Future oncology (London, England) - 1 Dec 2007
Trent Jonathan C, Lazar Alexander J F, Zhang Wei
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) and leiomyosarcomas (LMSs) are common types of mesenchymal tumors that may present a diagnostic challenge. GISTs have frequent overexpression of Kit and often encode for mutation of the KIT oncogene. In addition, patients usually experience a favorable response to targeted therapy with imatinib mesylate (Gleevec, STI-571), but not cytotoxic chemotherapy. Up to 5% of GISTs...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.