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Article

Novel Genomic Risk Stratification Model for Primary Gastrointestinal Stromal Tumors (GIST) in the Adjuvant Therapy Era.

Clinical cancer research : an official journal of the American Association for Cancer Research - 2 Oct 2023

Dermawan Josephine K, Kelly Ciara, Gao Zhidong, Smith Shaleigh, Jadeja Bhumika, Singer Samuel, Tap William D, Chi Ping, Antonescu Cristina R

Abstract excerpt

PURPOSE: Traditional risk stratification schemes in gastrointestinal stromal tumors (GIST) were defined in the pre-imatinib era and rely solely on clinicopathologic metrics. We hypothesize that genomic-based risk stratification is prognostically relevant in the current era of tyrosine kinase inhibitor (TKI) therapeutics. EXPERIMENTAL DESIGN: Comprehensive mutational and copy-number profiling using MSK-IMPACT was...

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Identifiers

PMID: 37477937
DOI: 10.1158/1078-0432.CCR-23-1184
PMCID: PMC11095631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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