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Article

Taking a Bad Turn: Compromised DNA Damage Response in Leukemia

4 May 2017

Abstract excerpt

Genomic integrity is of outmost importance for the survival at the cellular and the organismal level and key to human health. To ensure the integrity of their DNA, cells have evolved maintenance programs collectively known as the DNA damage response. Particularly challenging for genome integrity are DNA double-strand breaks (DSB) and defects in their repair are often associated with human disease, including...

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PMID: 28471392
DOI: 10.3390/cells6020011

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