Article

S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair

2022-03-27

Abstract excerpt

The mTORC1 substrate, S6 Kinase 1 (S6K1), is involved in the regulation of cell growth, ribosome biogenesis, glucose homeostasis and adipogenesis. Accumulating evidence has suggested a role for mTORC1 signaling in the DNA damage response. This is mostly based on the findings that mTORC1 inhibitors sensitized cells to DNA damage. However, a direct role of the mTORC1-S6K1 signaling pathway in DNA repair and the mech...

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Identifiers and source

Literature Corpus work: 480095ef-16f7-5e3a-91bc-8ae8b813d135
DOI: 10.1101/2022.03.25.485744

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