Article
Interplay between myotubularins and Ca2+ homeostasis.
Biochimica et biophysica acta. Molecular cell research - 1 Jun 2024
Dai Ning, Groenendyk Jody, Michalak Marek
Abstract excerpt
The myotubularin family, encompassing myotubularin 1 (MTM1) and 14 myotubularin-related proteins (MTMRs), represents a conserved group of phosphatases featuring a protein tyrosine phosphatase domain. Nine members are characterized by an active phosphatase domain C(X)5R, dephosphorylating the D3 position of PtdIns(3)P and PtdIns(3,5)P2. Mutations in myotubularin genes result in human myopathies, and several...
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