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Article

Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.

Molecular and cellular biology - 1 Sept 2000

Chi H, Yang X, Kingsley P D, O'Keefe R J, Puzas J E, Rosier R N, Shears S B, Reynolds P R

Abstract excerpt

Multiple inositol polyphosphate phosphatase (Minpp1) metabolizes inositol 1,3,4,5,6-pentakisphosphate (InsP(5)) and inositol hexakisphosphate (InsP(6)) with high affinity in vitro. However, Minpp1 is compartmentalized in the endoplasmic reticulum (ER) lumen, where access of enzyme to these predominantly cytosolic substrates in vivo has not previously been demonstrated. To gain insight into the physiological...

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Identifiers

PMID: 10938126
DOI: 10.1128/MCB.20.17.6496-6507.2000
PMCID: PMC86124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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