Article
A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection.
Cell - 10 Oct 2013
Zeron-Medina Jorge, Wang Xuting, Repapi Emmanouela, Campbell Michelle R, Su Dan, Castro-Giner Francesc, Davies Benjamin, Peterse Elisabeth F P, Sacilotto Natalia, Walker Graeme J, Terzian Tamara, Tomlinson Ian P, Box Neil F, Meinshausen Nicolai, De Val Sarah, Bell Douglas A, Bond Gareth L
Abstract excerpt
The ability of p53 to regulate transcription is crucial for tumor suppression and implies that inherited polymorphisms in functional p53-binding sites could influence cancer. Here, we identify a polymorphic p53 responsive element and demonstrate its influence on cancer risk using genome-wide data sets of cancer susceptibility loci, genetic variation, p53 occupancy, and p53-binding sites. We uncover a...
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