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Article

Investigating the functions of LARGE: lessons from mutant mice.

Methods in enzymology - 1 Jan 2010

Hewitt Jane E

Abstract excerpt

The Large gene encodes a predicted glycosyltransferase of undefined biological activity. However, one important target of the protein is known, alpha-dystroglycan. This protein is a key component of the dystrophin-associated glycoprotein in skeletal muscle, which links cytoskeletal actin to the extracellular matrix (ECM), stabilizing the muscle sarcolemmal membrane. alpha-Dystroglycan binds to extracellular...

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Identifiers

PMID: 20816177
DOI: 10.1016/S0076-6879(10)79021-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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