Article
Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse.
Nature genetics - 1 Jun 2001
Grewal P K, Holzfeind P J, Bittner R E, Hewitt J E
Abstract excerpt
Spontaneous and engineered mouse mutants have facilitated our understanding of the pathogenesis of muscular dystrophy and they provide models for the development of therapeutic approaches. The mouse myodystrophy (myd) mutation produces an autosomal recessive, neuromuscular phenotype. Homozygotes have an abnormal gait, show abnormal posturing when suspended by the tail and are smaller than littermate controls....
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