Article
Disruption of the mouse Large gene in the enr and myd mutants results in nerve, muscle, and neuromuscular junction defects.
Molecular and cellular neurosciences - 1 Apr 2005
Levedakou Eleni N, Chen Xiang-Jun, Soliven Betty, Popko Brian
Abstract excerpt
The autosomal recessive neuromuscular disorder associated with the enervated (enr) mouse transgene insertion manifests impaired peripheral nerve regeneration due to defects in Schwann cells and resembles the myodystrophy (Large(myd)) phenotype. Here we show that the enr transgene has integrated into Chr 8 approximately 160 kb downstream from the 3' end of the Large gene disrupting its expression as confirmed by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.