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Article

Mouse large can modify complex N- and mucin O-glycans on alpha-dystroglycan to induce laminin binding.

The Journal of biological chemistry - 27 May 2005

Patnaik Santosh K, Stanley Pamela

Abstract excerpt

The human LARGE gene encodes a protein with two putative glycosyltransferase domains and is required for the generation of functional alpha-dystroglycan (alpha-DG). Monoclonal antibodies IIH6 and VIA4-1 recognize the functional glycan epitopes of alpha-DG that are necessary for binding to laminin and other ligands. Overexpression of full-length mouse Large generated functionally glycosylated alpha-DG in Pro(-5)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15788414
DOI: 10.1074/jbc.M500069200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mouse large can modify complex N- and mucin O-glycans on alpha-dystroglycan to induce laminin binding.PMID 15788414Read ↗

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