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Article

Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein.

PloS one - 23 Aug 2010

Lawson Victoria A, Lumicisi Brooke, Welton Jeremy, Machalek Dorothy, Gouramanis Katrina, Klemm Helen M, Stewart James D, Masters Colin L, Hoke David E, Collins Steven J, Hill Andrew F

Abstract excerpt

BACKGROUND: The accumulation of protease resistant conformers of the prion protein (PrP(res)) is a key pathological feature of prion diseases. Polyanions, including RNA and glycosaminoglycans have been identified as factors that contribute to the propagation, transmission and pathogenesis of prio...

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Identifiers

PMID: 20808809
DOI: 10.1371/journal.pone.0012351
PMCID: PMC2925953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20808809-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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