Article
The interplay of glycosylation and disulfide formation influences fibrillization in a prion protein fragment.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003
Bosques Carlos J, Imperiali Barbara
Abstract excerpt
It is now accepted that the structural transition from cellular prion protein (PrPC) to proteinase K-resistant prion protein scrapie (PrPSc) is the major event leading to transmissible spongiform encephalopathies. Although the mechanism of this transition remains elusive, glycosylation has been proposed to impede the PrPC to PrPSc conversion. To address the role of glycosylation, we have prepared glycosylated and...
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