Article
A hypothesis describing a potential link between molecular structure and TSE strains.
Biochemical and biophysical research communications - 8 Sept 1997
Warwicker J
Abstract excerpt
In considering a protein-only model for prion pathogenesis in TSEs, one key challenge is to explain the existence of strains. These have traditionally been characterised by neuropathology and incubation times and more recently through biochemical analysis of prion protein (PrP), which shows differences in protease-resistant fragment size and glycoform ratios. It is now suggested that PrP possesses two faces which...
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