Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strain-specific role of RNAs in prion replication.

Journal of virology - 1 Oct 2012

Saá Paula, Sferrazza Gian Franco, Ottenberg Gregory, Oelschlegel Anja M, Dorsey Kerri, Lasmézas Corinne I

Abstract excerpt

Several lines of evidence suggest that various cofactors may be required for prion replication. PrP binds to polyanions, and RNAs were shown to promote the conversion of PrP(C) into PrP(Sc) in vitro. In the present study, we investigated strain-specific differences in RNA requirement during in vi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Assay
Share to Mice, Transgenic
Share to Prion Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prions

Share to Protein Folding

Share to Ribonuclease, Pancreatic

Share to Scrapie

Source

Open in PubMed Open full text

Identifiers

PMID: 22811520
DOI: 10.1128/JVI.01286-12
PMCID: PMC3457318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22811520-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Strain-specific role of RNAs in prion replication.PMID 22811520Read ↗

Prion replication environment defines the fate of prion strain adaptation.Semantic proximity Read ↗

Changes in prion replication environment cause prion strain mutation.Semantic proximity Read ↗

Prion protein PrP nucleic acid binding and mobilization implicates retroelements as the replicative component of transmissible spongiform encephalopathySemantic proximity Read ↗

Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.Semantic proximity Read ↗

Strain typing of classical scrapie by transgenic mouse bioassay using protein misfolding cyclic amplification to replace primary passage.Semantic proximity Read ↗

Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein.Semantic proximity Read ↗

Prion strain discrimination in cell culture: the cell panel assay.Semantic proximity Read ↗

D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.