Heparin-like molecules bind differentially to prion-proteins and change their intracellular metabolic fate.

doi:10.1002/jcp.1041570215

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Article

Heparin-like molecules bind differentially to prion-proteins and change their intracellular metabolic fate.

Journal of cellular physiology - 1 Nov 1993

Gabizon R, Meiner Z, Halimi M, Ben-Sasson S A

Abstract excerpt

PrPSc is the only known component of the scrapie prion. The difference between PrPSc and its normal isoform PrPc is probably conformational, since no difference has been found in the amino acid sequence or postranslational modifications between both proteins. Heparan sulfate (HS) has been shown t...

Topics

Amino Acids
Amyloid
Animals
Chlorates
Glycosaminoglycans
Heparin
Heparitin Sulfate
Immunohistochemistry
Isomerism
Mice
Neuroblastoma
Phenotype
PrPSc Proteins
Prions
Protein Conformation
Time Factors
Tumor Cells, Cultured

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