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Article

Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?

PloS one - 23 Aug 2010

Durrmeyer Xavier, Hovhannisyan Shushanik, Médard Yves, Jacqz-Aigrain Evelyne, Decobert Fabrice, Barre Jérome, Alberti Corinne, Aujard Yannick, Danan Claude, Baud Olivier

Abstract excerpt

BACKGROUND: Patent ductus arteriosus (PDA) in extremely preterm infants remains a challenging condition with conflicting treatment strategies. Ibuprofen is currently used to treat PDA with ductal closure failure rate up to 40%. We test the hypothesis that cytochrome P450 CYP2C8/2C9 polymorphisms may predict ibuprofen response. METHODOLOGY/PRINCIPAL FINDINGS: We studied extremely preterm neonates with...

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Identifiers

PMID: 20808793
DOI: 10.1371/journal.pone.0012329
PMCID: PMC2925896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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