Article
Genetic basis of apnoea of prematurity and caffeine treatment response: role of adenosine receptor polymorphisms: genetic basis of apnoea of prematurity.
Acta paediatrica (Oslo, Norway : 1992) - 1 Jul 2012
Kumral Abdullah, Tuzun Funda, Yesilirmak Didem Cemile, Duman Nuray, Ozkan Hasan
Abstract excerpt
AIM: Caffeine treatment reduces the frequency of apnoea of prematurity (AOP) and eliminates the need for mechanical ventilation by acting as a nonspecific inhibitor of adenosine A1 and adenosine 2A receptors. Patients with AOP have demonstrated variant responses to caffeine therapy. We proposed to investigate the role of A1 and 2A polymorphisms in the development of AOP and individual differences in caffeine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.