Article
Predicting nifedipine responses in preterm labor: a risk score incorporating ABCG2 polymorphisms and clinical factors.
Pharmacogenomics - 1 Jan 2025
Kim Jungsun, Han Ji Min, Yee Jeong, Kim Young Ju, Choi Suk Joo, Gwak Hye Sun
Abstract excerpt
BACKGROUND: Nifedipine, a substrate of ATP-binding cassette superfamily G member 2 (ABCG2), is a tocolytic agent. This study aimed to construct a scoring system by exploring the association between ABCG2 polymorphisms and the treatment response of nifedipine in pregnant women. METHODS: This study was conducted at a tertiary medical center. Eight single-nucleotide polymorphisms from the ABCG2 gene were selected....
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