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Article

Polymorphisms in CYP2C9 are associated with response to indomethacin among neonates with patent ductus arteriosus.

Pediatric research - 1 Nov 2017

Smith Caitlin J, Ryckman Kelli K, Bahr Timothy M, Dagle John M

Abstract excerpt

BackgroundPatent ductus arteriosus (PDA) is a common complication seen in preterm infants. Indomethacin is routinely used to treat PDA. Evidence suggests that the response of indomethacin is highly heritable. This study investigated the association between single-nucleotide polymorphisms (SNPs) in CYP2C9 and the closure of PDA in response to indomethacin.MethodsSix SNPs in CYP2C9 were analyzed for association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28609430
DOI: 10.1038/pr.2017.145
PMCID: PMC5645220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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