Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations affecting Leptospira interrogans lipopolysaccharide attenuate virulence

29 Aug 2010

Abstract excerpt

Leptospira interrogans is the causative agent of leptospirosis. Lipopolysaccharide (LPS) is the major outer membrane component of L. interrogans. It is the dominant antigen recognized during infection and the basis for serological classification. The structure of LPS and its role in pathogenesis are unknown. We describe two defined mutants of L. interrogans serovar Manilae with transposon insertions in the LPS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Leptospirosis research and findings
Share to Mycobacterium research and diagnosis
Share to Veterinary medicine and infectious diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20807198
DOI: 10.1111/j.1365-2958.2010.07360.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations affecting Leptospira interrogans lipopolysaccharide attenuate virulencePMID 20807198Read ↗

Characterization of a lipopolysaccharide mutant of Leptospira derived by growth in the presence of an anti-lipopolysaccharide monoclonal antibody.Semantic proximity Read ↗

Cross-protective immunity against leptospirosis elicited by a live, attenuated lipopolysaccharide mutant.Semantic proximity Read ↗

Leptospiral LruA is required for virulence and modulates an interaction with mammalian apolipoprotein AI.Semantic proximity Read ↗

Comparative Genomics of Two <i>Leptospira interrogans</i> Serovars Reveals Novel Insights into Physiology and PathogenesisSemantic proximity Read ↗

CRISPR-based mutagenesis of lipopolysaccharide biosynthesis genes in Leptospira interrogans reveals gene essentiality and confirms the role of an O-antigen polymerase.Semantic proximity Read ↗

Genome features of Leptospira interrogans serovar CopenhageniSemantic proximity Read ↗

Characterization of IS1501 mutants of Leptospira interrogans serovar pomona.Semantic proximity Read ↗

Transposon Sequencing in Leptospira interrogans.Semantic proximity Read ↗

Inactivation of clpB in the pathogen Leptospira interrogans reduces virulence and resistance to stress conditions.Semantic proximity Read ↗

Random mutagenesis of Legionella pneumophila reveals genes associated with lipopolysaccharide synthesis and recognition by typing monoclonal antibodies.Semantic proximity Read ↗

Leptospiral Outer Membrane Protein LipL41 Is Not Essential for Acute Leptospirosis but Requires a Small Chaperone Protein, Lep, for Stable ExpressionSemantic proximity Read ↗

Transcriptional Responses of Leptospira interrogans to Host Innate Immunity: Significant Changes in Metabolism, Oxygen Tolerance, and Outer MembraneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.