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Article

Inactivation of clpB in the pathogen Leptospira interrogans reduces virulence and resistance to stress conditions.

Infection and immunity - 1 Sept 2011

Lourdault Kristel, Cerqueira Gustavo M, Wunder Elsio A, Picardeau Mathieu

Abstract excerpt

Leptospira interrogans is the causative agent of leptospirosis, which is an emerging zoonotic disease. Resistance to stress conditions is largely uncharacterized for this bacterium. We therefore decided to analyze a clpB mutant that we obtained by random transposon mutagenesis. The mutant did not produce any of the two isoforms of ClpB. The clpB mutant exhibited growth defects at 30° and 37°C and in poor nutrient...

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Identifiers

PMID: 21730091
DOI: 10.1128/IAI.05168-11
PMCID: PMC3165490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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