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Article

Cross-protective immunity against leptospirosis elicited by a live, attenuated lipopolysaccharide mutant.

The Journal of infectious diseases - 15 Mar 2011

Srikram Amporn, Zhang Kunkun, Bartpho Thanatchaporn, Lo Miranda, Hoke David E, Sermswan Rasana W, Adler Ben, Murray Gerald L

Abstract excerpt

BACKGROUND: Leptospira species cause leptospirosis, a zoonotic disease found worldwide. Current vaccines against leptospirosis provide protection only against closely related serovars. METHODS: We evaluated an attenuated transposon mutant of Leptospira interrogans serovar Manilae (M1352, defective in lipopolysaccharide biosynthesis) as a live vaccine against leptospirosis. Hamsters received a single dose of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21220775
DOI: 10.1093/infdis/jiq127
PMCID: PMC3071135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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