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Article

Leptospiral LruA is required for virulence and modulates an interaction with mammalian apolipoprotein AI.

Infection and immunity - 1 Oct 2013

Zhang Kunkun, Murray Gerald L, Seemann Torsten, Srikram Amporn, Bartpho Thanatchaporn, Sermswan Rasana W, Adler Ben, Hoke David E

Abstract excerpt

Leptospirosis is a worldwide zoonosis caused by spirochetes of the genus Leptospira. While understanding of pathogenesis remains limited, the development of mutagenesis in Leptospira has provided a powerful tool for identifying novel virulence factors. LruA is a lipoprotein that has been implicated in leptospiral uveitis as a target of the immune response. In this study, two lruA mutants, M754 and M765, generated...

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Identifiers

PMID: 23918777
DOI: 10.1128/IAI.01195-12
PMCID: PMC3811782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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