Manipulating the Folding Landscape of a Multidomain Protein.

doi:10.1021/acs.jpcb.8b04834

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Article

Manipulating the Folding Landscape of a Multidomain Protein.

The journal of physical chemistry. B - 13 Dec 2018

Kantaev Raisa, Riven Inbal, Goldenzweig Adi, Barak Yoav, Dym Orly, Peleg Yoav, Albeck Shira, Fleishman Sarel J, Haran Gilad

Abstract excerpt

Folding of proteins to their functional conformation is paramount to life. Though 75% of the proteome consists of multidomain proteins, our knowledge of folding has been based primarily on studies conducted on single-domain and fast-folding proteins. Nonetheless, the complexity of folding landscapes exhibited by multidomain proteins has received increased scrutiny in recent years. We study the three-domain...

Topics

Adenylate Kinase
Escherichia coli
Fluorescence Resonance Energy Transfer
Mutation
Protein Engineering
Protein Folding

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PMID: 30088929
DOI: 10.1021/acs.jpcb.8b04834

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