Article
MRS in early and presymptomatic carriers of a novel octapeptide repeat insertion in the prion protein gene.
Journal of neuroimaging : official journal of the American Society of Neuroimaging - 1 Jul 2013
McDade Eric M, Boeve Bradley F, Fields Julie A, Kumar Neeraj, Rademakers Rosa, Baker Matt C, Knopman Bsc David S, Petersen Ronald C, Jack Clifford R, Kantarci Kejal
Abstract excerpt
To evaluate the proton magnetic resonance (MR) spectroscopy ((1) H MRS) changes in carriers of a novel octapeptide repeat insertion in the prion protein gene (PRNP) and family history of frontotemporal dementia with ataxia. Four at-risk mutation carriers and 13 controls were compared using single voxel, short TE, (1) H MRS from the posterior cingulate gyrus. The mutation carriers had an increased...
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