Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers.

doi:10.1111/jon.12642

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Article

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers.

Journal of neuroimaging : official journal of the American Society of Neuroimaging - 1 Sept 2019

Chen Qin, Boeve Bradley F, Tosakulwong Nirubol, Lesnick Timothy, Brushaber Danielle, Dheel Christina, Fields Julie, Forsberg Leah, Gavrilova Ralitza, Gearhart Debra, Haley Dana, Gunter Jeffrey L, Graff-Radford Jonathan, Jones David, Knopman David, Graff-Radford Neill, Kraft Ruth, Lapid Maria, Rademakers Rosa, Wszolek Zbigniew K, Rosen Howie, Boxer Adam L, Kantarci Kejal

Abstract excerpt

BACKGROUND AND PURPOSE: The objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the neurochemical alterations accelerated during disease progression. METHODS: We identified eight MAPT mutations carriers who transitioned from asymptomatic to...

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PMID: 31173437
DOI: 10.1111/jon.12642
PMCID: PMC6731148

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MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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