Article
Analysis of GNAQ mutations, proliferation and MAPK pathway activation in uveal melanomas.
The British journal of ophthalmology - 1 May 2011
Pópulo Helena, Vinagre João, Lopes José Manuel, Soares Paula
Abstract excerpt
AIM: To study the GNAQ mutational status in a series of uveal melanomas and evaluate possible associations with mitogen-activated protein kinase (MAPK) pathway protein expression and tumour proliferation markers. METHODS: Mutational analysis was performed by PCR/sequencing of exon 5 of the GNAQ gene in a series of 22 uveal melanomas in which total and phosphorylated extracellular signal-regulated kinase (ERK) 1/2...
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