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Article

Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish.

Oncotarget - 28 Jun 2016

Mouti Mai Abdel, Dee Christopher, Coupland Sarah E, Hurlstone Adam F L

Abstract excerpt

Mutations affecting Gαq proteins are pervasive in uveal melanoma (UM), suggesting they 'drive' UM pathogenesis. The ERK1/2-MAPK pathway is critical for cutaneous melanoma development and consequently an important therapeutic target. Defining the contribution of ERK1/2-MAPK signalling to UM development has been hampered by the lack of an informative animal model that spontaneously develops UM. Towards this end, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27166257
DOI: 10.18632/oncotarget.9207
PMCID: PMC5129960

Genes

GNAQ

Provenance

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