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Article

HIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays

15 Feb 2010

Abstract excerpt

BACKGROUND: HIV-1 infected patients for whom standard gp160 phenotypic tropism testing failed are currently excluded from co-receptor antagonist treatment. To provide patients with maximal treatment options, massively parallel sequencing of the envelope V3 domain, in combination with tropism prediction tools, was evaluated as an alternative tropism determination strategy. Plasma samples from twelve HIV-1 infected...

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PMID: 20804564
DOI: 10.1186/1742-6405-7-4

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