Article
Quercetin enhances human α7 nicotinic acetylcholine receptor-mediated ion current through interactions with Ca(2+) binding sites.
Molecules and cells - 1 Sept 2010
Lee Byung-Hwan, Choi Sun-Hye, Shin Tae-Joon, Pyo Mi Kyung, Hwang Sung-Hee, Kim Bo-Ra, Lee Sang-Mok, Lee Jun-Ho, Kim Hyoung-Chun, Park Hye-Young, Rhim Hyewhon, Nah Seung-Yeol
Abstract excerpt
The flavonoid quercetin is a low molecular weight substance found in fruits and vegetables. Aside from its anti-oxidative effect, quercetin, like other flavonoids, has a wide range of neuropharmacological actions. The α7 nicotinic acetylcholine receptor (α7 nAChR) has a Ca(2+)-binding site, is highly permeable to the Ca(2+) ion, and plays important roles in Ca(2+)-related normal brain functions. Dysfunctions of...
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