Article

Aluminium alters excitability by inhibiting calcium, sodium and potassium currents in bovine chromaffin cells

2023-01-25

Abstract excerpt

Aluminium (Al 3+ ) has long been related to neurotoxicity and neurological diseases. This study aims to describe the specific actions of this metal on cellular excitability and neurotransmitter release. Al 3+ reduced intracellular calcium concentrations around 25% and decreased catecholamine secretion in a dose-dependent manner, with an IC 50 of 89.1 μM. Al 3+ blocked calcium currents in a time- and concentrat...

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Literature Corpus work: d3e02a8f-7d98-5fb3-a343-18988dbc961a
DOI: 10.1101/2023.01.25.525351

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