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Article

Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis.

Cell regulation - 1 Jul 1990

Marcantonio E E, Guan J L, Trevithick J E, Hynes R O

Abstract excerpt

We describe here the expression of deletion mutants of the cytoplasmic domain of the avian integrin beta 1 subunit. These mutants, which contain termination codons at positions 767, 776, 791, and 800, were transfected into mouse 3T3 cells to determine which sequences were essential for localization of integrins into focal contact sites. In all cases, high-level expression of the truncated avian integrins was...

Topics

Amino Acid Sequence
Animals
Binding Sites
Cell Line
Chickens
Consensus Sequence
Cytoplasm
Cytoskeletal Proteins
Fluorescent Antibody Technique
Integrins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis, Site-Directed

Mutation

Precipitin Tests

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2078570
DOI: 10.1091/mbc.1.8.597
PMCID: PMC361602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2078570-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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