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Article

Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry.

Retrovirology - 8 Jun 2006

Bourgeois Rachel, Mercier Johanne, Paquette-Brooks Isabelle, Cohen Eric A

Abstract excerpt

BACKGROUND: Human immunodeficiency virus (HIV) enters target cells by a membrane fusion process that involves a series of sequential interactions between its envelope glycoproteins, the CD4 receptor and CXCR4/CCR5 coreceptors. CD4 molecules are expressed at the cell surface of lymphocytes and monocytes mainly as monomers, but basal levels of CD4 dimers are also present at the cell surface of these cells. Previous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16762062
DOI: 10.1186/1742-4690-3-31
PMCID: PMC1524797

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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