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Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis

24 Aug 2010

Abstract excerpt

BACKGROUND: The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS: Two cohorts were compared: one was a group with young-onset PrCa, tested for germline BRCA2 mutations (6 of 263 cases had a germline BRAC2 mutation), and the...

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PMID: 20736950
DOI: 10.1038/sj.bjc.6605822

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