Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene.

doi:10.1086/345310

Article

Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene.

American journal of human genetics - 1 Jan 2003

Edwards Stephen M, Kote-Jarai Zsofia, Meitz Julia, Hamoudi Rifat, Hope Questa, Osin Peter, Jackson Rachel, Southgate Christine, Singh Rashmi, Falconer Alison, Dearnaley David P, Ardern-Jones Audrey, Murkin Annette, Dowe Anna, Kelly Jo, Williams Sue, Oram Richard, Stevens Margaret, Teare Dawn M, Ponder Bruce A J, Gayther Simon A, Easton Doug F, Eeles Rosalind A

Abstract excerpt

Studies of families with breast cancer have indicated that male carriers of BRCA2 mutations are at increased risk of prostate cancer, particularly at an early age. To evaluate the contribution of BRCA2 mutations to early-onset prostate cancer, we screened the complete coding sequence of BRCA2 for...

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Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene.

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