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Article

DNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancer.

Cancer medicine - 1 May 2017

Takane Kiyoko, Akagi Kiwamu, Fukuyo Masaki, Yagi Koichi, Takayama Tadatoshi, Kaneda Atsushi

Abstract excerpt

Sporadic colorectal cancer (CRC) is classified into several molecular subtypes. We previously established two groups of DNA methylation markers through genome-wide DNA methylation analysis to classify CRC into distinct subgroups: high-, intermediate-, and low-methylation epigenotypes (HME, IME, and LME, respectively). HME CRC, also called CpG island methylator phenotype (CIMP)-high CRC, shows methylation of both...

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Identifiers

PMID: 28378457
DOI: 10.1002/cam4.1061
PMCID: PMC5430106

Genes

NRAS
KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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