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Article

Geographical structure of diversity and differences between symptomatic and asymptomatic infections for Plasmodium falciparum vaccine candidate AMA1.

Infection and immunity - 1 Mar 2003

Cortés Alfred, Mellombo Mata, Mueller Ivo, Benet Ariadna, Reeder John C, Anders Robin F

Abstract excerpt

Plasmodium falciparum apical membrane antigen 1 (AMA1) is a prime malaria vaccine candidate. Antigenic diversity within parasite populations is one of the main factors potentially limiting the efficacy of any asexual-stage vaccine, including one based on AMA1. The DNA coding for the most variable region of this antigen, domain I, was sequenced in 168 samples from the Wosera region of Papua New Guinea, including...

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Identifiers

PMID: 12595459
DOI: 10.1128/IAI.71.3.1416-1426.2003
PMCID: PMC148836

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Source receipt: pubmed, retrieved 7 Sept 2026.

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