Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents.

doi:10.1111/j.1369-1600.2010.00239.x

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Article

Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents.

Addiction biology - 1 Jul 2011

Desrivières Sylvane, Lourdusamy Anbarasu, Müller Christian, Ducci Francesca, Wong Cybele P, Kaakinen Marika, Pouta Anneli, Hartikainen Anna-Liisa, Isohanni Matti, Charoen Pimphen, Peltonen Leena, Freimer Nelson, Elliott Paul, Jarvelin Marjo-Riitta, Schumann Gunter

Abstract excerpt

Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n=4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465)...

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PMID: 20731635
DOI: 10.1111/j.1369-1600.2010.00239.x
PMCID: PMC3428936

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