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Article

Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis.

PloS one - 13 Aug 2010

Bu Wenyu, Lim Kim Buay, Yu Yuan Hong, Chou Ai Mei, Sudhaharan Thankiah, Ahmed Sohail

Abstract excerpt

Transducer of Cdc42-dependent actin assembly (Toca-1) consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain. Toca-1 interacts with N-WASP, an activator of actin nucleation that binds Cdc42. Cdc42 may play an important role in regulating Toca-1 and N-WASP functions. We report here that the cellular expression of Toca-1 and N-WASP induces membrane tubulation and the formation of motile vesicles....

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Identifiers

PMID: 20730103
DOI: 10.1371/journal.pone.0012153
PMCID: PMC2921345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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