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Article

Regulation of limb patterning by extracellular microfibrils.

The Journal of cell biology - 23 Jul 2001

Arteaga-Solis E, Gayraud B, Lee S Y, Shum L, Sakai L, Ramirez F

Abstract excerpt

To elucidate the contribution of the extracellular microfibril-elastic fiber network to vertebrate organogenesis, we generated fibrillin 2 (Fbn2)-null mice by gene targeting and identified a limb-patterning defect in the form of bilateral syndactyly. Digit fusion involves both soft and hard tissues, and is associated with reduced apoptosis at affected sites. Two lines of evidence suggest that syndactily is...

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Source

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Identifiers

PMID: 11470817
DOI: 10.1083/jcb.200105046
PMCID: PMC2150751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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