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Article

Microenvironmental Regulation by Fibrillin-1

5 Jan 2012

Abstract excerpt

Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes. A role for fibrillin-1 in specifying tissue microenvironments has not been elucidated, even though the concept that fibrillin-1 provides extracellular control of growth factor signaling is currently appreciated. Mutations in FBN1 are mainly responsible for the Marfan syndrome (MFS), recognized by its...

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PMID: 22242013
DOI: 10.1371/journal.pgen.1002425

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