Article
The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease.
European heart journal - 1 Dec 2010
Patel Riyaz S, Su Shaoyong, Neeland Ian J, Ahuja Ayushi, Veledar Emir, Zhao Jinying, Helgadottir Anna, Holm Hilma, Gulcher Jeffrey R, Stefansson Kari, Waddy Salina, Vaccarino Viola, Zafari A Maziar, Quyyumi Arshed A
Abstract excerpt
AIMS: we tested the hypothesis that the 9p21 risk locus promotes atherosclerosis by examining the association between rs10757278 and coronary artery disease (CAD) severity and progression determined by semi-quantitative angiographic scores. METHODS AND RESULTS: the rs10757278 single nucleotide polymorphism (SNP) was genotyped as the marker for the 9p21 locus in 2334 Caucasian patients undergoing cardiac...
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