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Article

Ion channels, long QT syndrome and arrhythmogenesis in ageing.

Clinical and experimental pharmacology & physiology - 1 Dec 2017

Jeevaratnam Kamalan, Chadda Karan R, Salvage Samantha C, Valli Haseeb, Ahmad Shiraz, Grace Andrew A, Huang Christopher L-H

Abstract excerpt

Ageing is associated with increased prevalences of both atrial and ventricular arrhythmias, reflecting disruption of the normal sequence of ion channel activation and inactivation generating the propagated cardiac action potential. Experimental models with specific ion channel genetic modifications have helped clarify the interacting functional roles of ion channels and how their dysregulation contributes to...

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Identifiers

PMID: 28024120
DOI: 10.1111/1440-1681.12721
PMCID: PMC5763326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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