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Article

Arrhythmias precede cardiomyopathy and remodeling of Ca2+ handling proteins in a novel model of long QT syndrome.

Journal of molecular and cellular cardiology - 1 Oct 2018

Montnach Jérôme, Chizelle Franck F, Belbachir Nadjet, Castro Claire, Li Linwei, Loussouarn Gildas, Toumaniantz Gilles, Carcouët Agnès, Meinzinger Anne Julia, Shmerling Doron, Benitah Jean-Pierre, Gómez Ana Maria, Charpentier Flavien, Baró Isabelle

Abstract excerpt

AIM: Deletion of QKP1507-1509 amino-acids in SCN5A gene product, the voltage-gated Na+ channel Nav1.5, has been associated with a large phenotypic spectrum of type 3 long QT syndrome, conduction disorder, dilated cardiomyopathy and high incidence of sudden death. The aim of this study was to develop and characterize a novel model of type 3 long QT syndrome to study the consequences of the QKP1507-1509 deletion....

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Identifiers

PMID: 30144447
DOI: 10.1016/j.yjmcc.2018.08.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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