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Article

Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.

Journal of cell science - 15 Feb 2002

Kheradmand Farrah, Rishi Kirtee, Werb Zena

Abstract excerpt

Epithelial-mesenchymal interactions during lung development require extracellular signaling factors that facilitate branching morphogenesis. We show here that matrix metalloproteinases (MMPs) originating in the mesenchyme are necessary for epithelial branching and alveolization. We found that the delayed lung maturation characterized by abnormal branching and poor alveolization seen in mice deficient in epidermal...

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Source

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Identifiers

PMID: 11865039
DOI: 10.1242/jcs.115.4.839
PMCID: PMC2788991

Genes

MMP2
EGF
MMP14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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