Article
Prevalence of dihydropteroate synthase genotypes before and after the introduction of combined antiretroviral therapy and their influence on the outcome of Pneumocystis pneumonia in HIV-1-infected patients.
Diagnostic microbiology and infectious disease - 1 Sept 2010
Alvarez-Martínez Míriam J, Miró José M, Valls Maria Eugenia, Mas Jordi, de la Bellacasa Jorge Puig, Sued Omar, Solé Manel, Rivas Paula V, de Lazzari Elisa, Benito Natividad, García Felipe, Agustí Carlos, Wilson Paul E, Gatell José M, Jiménez de Anta Maria Teresa, Meshnick Steven R, Moreno Asunción
Abstract excerpt
The objective of this study was to determine whether the prevalence of Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations has changed since the introduction of combined antiretroviral therapy (cART) and whether the mutations are associated with poor outcome in Spanish HIV-1-infected patients with Pneumocystis pneumonia (PcP). We studied 167 PcP episodes in HIV-1-infected patients diagnosed...
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