Article
Blood outgrowth endothelial cell-based systemic delivery of antiangiogenic gene therapy for solid tumors.
Cancer gene therapy - 1 Dec 2010
Bodempudi V, Ohlfest J R, Terai K, Zamora E A, Vogel R I, Gupta K, Hebbel R P, Dudek A Z
Abstract excerpt
Endothelial cells and endothelial cell precursors encoding a therapeutic gene have induced antitumor responses in preclinical models. Culture of peripheral blood provides a rich supply of autologous, highly proliferative endothelial cells, also referred to as blood outgrowth endothelial cells (BOECs). The aim of this study was to evaluate a novel antiangiogenic strategy using BOECs expressing fms-like tyrosine...
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