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<i>In Vivo</i> Targeting of Tumor Endothelial Cells by Systemic Delivery of Lentiviral Vectors

23 Jul 2003

Abstract excerpt

Tumor angiogenesis is a rate-limiting factor for tumor growth, and the endothelial cells of tumor vessels display specific features that can be exploited for the selective delivery of cancer therapeutics. To specifically target exogenous genes to angiogenic tumor vessels, we generated a panel of vesicular stomatitis virus-pseudotyped lentiviral vectors (LVs) engineered for endothelial cell (EC)-specific...

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PMID: 12908970
DOI: 10.1089/104303403322168028

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