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Article

In vivo evolution of tumor-derived endothelial cells.

PloS one - 1 Jan 2012

McGuire Terence F, Sajithlal Gangadharan B, Lu Jie, Nicholls Robert D, Prochownik Edward V

Abstract excerpt

The growth of a malignant tumor beyond a certain, limited size requires that it first develop an independent blood supply. In addition to providing metabolic support, this neovasculature also allows tumor cells to access the systemic circulation, thus facilitating metastatic dissemination. The neovasculature may originate either from normal blood vessels in close physical proximity to the tumor and/or from the...

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Identifiers

PMID: 22623986
DOI: 10.1371/journal.pone.0037138
PMCID: PMC3356387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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